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Its duration of analgesia is about three to seven hours.

However, concerns exist that morphine may increase mortality in the setting of non ST elevation myocardial infarction. Morphine has also traditionally been used in the treatment of acute pulmonary edema. A 2006 review, though, found little evidence to support this practice. A 2016 Cochrane review concluded that morphine is effective in relieving cancer pain. Side-effects of nausea and constipation are rarely severe enough to warrant stopping treatment.

Maximum effect is around 20 minutes when given intravenously and 60 minutes when given by mouth, while duration of effect is 3–7 hours. Long-acting formulations also exist.

Potentially serious side effects include a decreased respiratory effort and low blood pressure. Morphine has a high potential for addiction and abuse. Common side effects include drowsiness, vomiting, and constipation.

Morphine was first isolated between 1803 and 1805 by Friedrich Sertürner. Merck began marketing it commercially in 1827. Sertürner originally named the substance morphium after the Greek god of dreams, Morpheus, as it has a tendency to cause sleep.

The primary source of morphine is isolation from poppy straw of the opium poppy.  the last twenty years. Most use for this purpose was in the developed world. It is a Schedule II drug in the United States, Class A in the United Kingdom, and Schedule I in Canada. It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system.

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